The design, synthesis and cardiorenal actions of a new chimeric natriuretic peptide CD-NP
نویسندگان
چکیده
منابع مشابه
Design, synthesis, and actions of a novel chimeric natriuretic peptide: CD-NP.
OBJECTIVES Our aim was to design, synthesize and test in vivo and in vitro a new chimeric peptide that would combine the beneficial properties of 2 distinct natriuretic peptides with a biological profile that goes beyond native peptides. BACKGROUND Studies have established the beneficial vascular and antiproliferative properties of C-type natriuretic peptide (CNP). While lacking renal actions...
متن کاملAC-NP: A Novel Chimeric Peptide with Natriuretic and Vasorelaxing Actions
The aim of this study was to evaluate the cardiovascular and renal activities of a newly designed natriuretic peptide (NP). Here, we engineered a novel 28-amino acid chimeric peptide, termed AC-NP that combined the 17-amino acid ring of C type natriuretic peptide (CNP) with the 6-amino acid N-terminus and 5-amino acid C-terminus of atrial natriuretic peptide (ANP). Both in vitro and in vivo exp...
متن کاملTreatment with CBA-NP a novel chimeric natriuretic peptide attenuates cardiorenal fibrosis and improves diastolic dysfunction in diabetic rat model
Introduction Diabetes is a major risk factor for left ventricular dysfunction with cardiac and renal fibrosis. C-type natriuretic peptide (CNP) is a 22 amino-acid peptide produced mainly in the cardiac endothelium with potent cardiac unloading, anti-fibrotic and antihypertensive effects, but minimal renal actions. Using this knowledge we designed a natriuretic peptide CBA-NP by fusing a 6 AA se...
متن کاملThe novel dual GC-A and GC-B designer natriuretic peptide, cenderitide (CD-NP), enhances the renal actions of furosemide in a model of severe heart failure
Background Patients with congestive heart failure (HF) have symptomatic improvement with diuretic therapy, although with time diuretic resistance and renal dysfunction can occur. Cenderitide (also known as CD-NP), now in clinical trials in patients with HF, is a Mayo designed chimeric natriuretic peptide which, unlike the native natriuretic peptides (NPs) ANP, BNP and CNP, binds both to guanyly...
متن کاملRole of the natriuretic peptide system in cardiorenal protection.
Significant progress has been made in the understanding of the neurohormonal factors that contribute to the progression of chronic renal and cardiac failure and the development of target-organ damage in patients with hypertension and diabetes. We herein review some of these advances, including a new therapeutic strategy for potentially enhancing cardiorenal protection in patients with these dis...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2003
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(03)82460-9